TMEM175
TMEM175 is a lysosomal potassium channel that maintains lysosomal membrane potential, ion balance, and enzymatic competence—functions that are essential for effective autophagy and substrate degradation. Loss-of-function variants in TMEM175 represent one of the strongest and most reproducible genetic risk factors for Parkinson’s disease, linking impaired TMEM175 activity to disrupted lysosomal physiology, α-synuclein accumulation, and dopaminergic neuron vulnerability.
Lysoway has developed highly brain-penetrant, potent small-molecule TMEM175 agonists that directly restore this deficient channel activity. By re-establishing lysosomal ion homeostasis and improving degradative capacity, our molecules enhance clearance of pathogenic substrates central to PD progression. TMEM175 agonism offers a genetically validated, upstream mechanism tailored specifically for Parkinson’s disease, complementing Lysoway’s broader lysosomal restoration platform.
