TRPML1
TRPML1 (Transient Receptor Potential Mucolipin-1) is a master regulator of lysosomal calcium release, trafficking, membrane repair, and autophagy resolution. Genetic and functional studies show that TRPML1 activity is diminished across multiple age-related neurodegenerative diseases.
Lysoway has developed highly brain-penetrant, potent small-molecule TRPML1 agonists that directly restore this impaired signaling. By re-establishing proper lysosomal function, our molecules enhance the degradation of harmful protein and lipid aggregates, damaged organelles—helping neurons clear the stressors that accumulate with age and disease. This upstream, systems-level mechanism offers broad applicability across CNS disorders and represents a fundamentally different approach to treating neurodegeneration.
